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Symbol
Name
ID

Unc93b1
unc-93 homolog B1, TLR signaling regulator
MGI:1859307

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

decreased B cell proliferation

increased B cell proliferation

enlarged spleen

increased spleen weight

abnormal T-helper 1 cell differentiation

abnormal T-helper 17 cell differentiation

decreased marginal zone B cell number

increased B cell number

increased CD4-positive, alpha-beta memory T cell number

increased T-helper 1 cell number

increased T-helper 17 cell number

increased memory T cell number

abnormal dendritic cell morphology

increased IgG2a level

increased IgG2b level

abnormal macrophage physiology

abnormal circulating interferon level

decreased circulating interleukin-12b level

decreased circulating interleukin-6 level

increased circulating tumor necrosis factor level

abnormal tumor necrosis factor level

abnormal dendritic cell physiology

abnormal dendritic cell antigen presentation

abnormal antigen presentation via MHC class I

abnormal antigen presentation via MHC class II

abnormal cytokine secretion

decreased interferon-alpha secretion

increased interferon-alpha secretion

decreased interleukin-12b secretion

increased interleukin-12b secretion

decreased interleukin-6 secretion

abnormal tumor necrosis factor secretion

decreased tumor necrosis factor secretion

increased tumor necrosis factor secretion

increased autoantibody level

increased anti-nuclear antigen antibody level

liver inflammation

glomerulonephritis

increased susceptibility to bacterial infection

increased susceptibility to Herpesvirales infection

Availability

Mouse Genotype

Unc93b1^3d/Unc93b1^3d

Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg}

Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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